| Saturday, February 29, 2020 | ||
| DC United | 1 -2 | Colorado Rapids |
| Houston Dynamo | 1 -1 | Los Angeles Galaxy |
| San Jose Earthquake | 2 -2 | Toronto FC |
| FC Dallas | 2 -0 | Philadelphia Union |
| Orlando City FC | 0 -0 | Real Salt Lake |
| Nashville FC | 1 -2 | Atlanta United FC |
| Vancouver Whitecaps FC | 1 -3 | Sporting Kansas City |
| Sunday, March 1, 2020 | ||
| Columbus Crew FC | 1-0 | New York City FC |
| New York Red Bulls | 3-2 | FC Cincinnati |
| Seattle Sounders FC | 2-1 | Chicago Fire FC |
| Los Angeles FC | 1-0 | Inter Miami CF |
| Portland Timbers | 1-3 | Minnesota United FC |
MLS Schedule Game 2
| Saturday, March 7, 2020 | ||
| New England Revolution | Chicago Fire | |
| Real Salt Lake | New York Red Bulls | |
| FC Dallas | Montreal Impact | |
| DC United | Inter Miami CF | |
| Toronto FC | New York City FC | |
| Atlanta United FC | FC Cincinnati | |
| San Jose Earthquakes | Minnesota United FC | |
| Sporting Kansas City | Houston Dynamo | |
| Colorado Rapids | Orlando City SC | |
| LA Galaxy | Vancouver Whitecaps FC | |
| Seattle Sounders FC | Columbus Crew SC |
| Sunday, March 8, 2020 | ||
| Portland Timbers | Nashville SC | |
| Los Angeles FC | Philadelphia Union |
MLS Schedule Game 3
| Saturday, March 14, 2020 | ||
| New York City FC | Fc Dallas | |
| Inter Miami CF | Los Angeles Galaxy | |
| Toronto FC | Nashville | |
| Columbus Crew SC | Real Salt Lake | |
| FC Cincinnati | DC United | |
| Atlanta United FC | Sporting Kansas City | |
| Vancouver Whitecaps FC | Colorado Rapids | |
| Philadelphia Union | San Jose Earthquakes | |
| Orlando City SC | Chicago Fire FC | |
| Houston Dynamo | Seattle Sounders FC |
| Sunday, March 15, 2020 | | |
| New England Revolution | | Portland Timbers |
| Minnesota United FC | | New York Red Bulls |
MLS Schedule Game 4
| Saturday, March 21, 2020 | | |
| New York City FC | | Vancouver Whitecaps FC |
| Nashville SC | | Columbus Crew SC |
| FC Cincinnati | | Toronto FC |
| Minnesota United | | Montreal Impact |
| Chicago Fire FC | | Atlanta United FC |
| Inter Miami CF | | New York Red Bulls |
| Colorado Rapids | | Houston Dynamo |
| Real Salt Lake | | New England Revolution |
| San Jose Earthquakes | | Sporting Kansas City |
| Seattle Sounders FC | | Fc Dallas |
| Sunday, March 22, 2020 | | |
| Philadelphia Union | | DC United |
| LA Galaxy | | Orlando City SC |
| Los Angeles FC | | Portland Timbers |
MLS Schedule Game 5
| Saturday, March 28, 2020 | | |
| New York Red Bulls | | Orlando City SC |
| Sporting Kansas City | | Real Salt Lake |
| Portland Timbers | | Philadelphia Union |
| Friday, April 3, 2020 | | |
| DC United | | New York City FC |
| Nashville SC | | Seattle Sounders FC |
| Saturday, April 4, 2020 | | |
| Chicago Fire FC | | New York Red BUlls |
| Orlando City SC | | Montreal Impact |
| FC Dallas | | Los Angeles FC |
| Colombus Crew SC | | Toronto FC |
| Houston Dynamo | | Portland Timbers |
| New England Revolution | | Colorado Rapids |
| Minnesota United FC | | San Jose Earthquakes |
| Vancouver Whitecaps FC | | Real Salt Lake |
| LA Galaxy | | Sporting Kansas City |
| Sunday, April 5, 2020 | | |
| Inter Miami CF | | Philadelphia Union |
| Fc Cincinnati | | Atlanta United FC |
MLS Schedule Game 6
| Saturday, April 11, 2020 | | |
| Philadelphia Union | | Montreal Impact |
| Houston Dynamo | | Inter Miami CF |
| San Jose Earthquakes | | DC United |
| Columbus Crew SC | | Orlando City SC |
| New England Revolution | | FC Cincinnati |
| Toronto FC | | New York Red Bulls |
| Minnesota United FC | | LA Galaxy |
| Nashville SC | | Sporting Kansas City |
| Real Salt Lake | | Colorado Rapids |
| Vancouver Whitecaps FC | | Los Angeles FC |
| Portland Timbers | FC Dallas |
| Sunday, April 12, 2020 | | |
| New York City FC | | Chicago Fire FC |
MLS Schedule Game 7
| Wednesday, April 15, 2020 | | |
| DC United | | Toronto FC |
| Philadelphia Union | | LA Galaxy |
| Houston Dynamo | | Minnesota United FC |
| Colorado Rapids | | San Jose Earthquakes |
| Saturday, April 18, 2020 | | |
| Montreal Impact | | Houston DYnamo |
| New York Red Bulls | | New England Revolution |
| Toronto FC | | LA Galaxy |
| Inter Miami CF | | San Jose Earthquakes |
| Orlando City SC | | FC Cincinnati |
| Minnesota United FC | | FC Dallas |
| Nashville FC | | DC United |
| Sporting Kansas City | | Colorado Rapids |
| Seattle Sounders FC | | Vancouver Whitecaps FC |
| Los Angeles FC | | Real Salt Lake |
| Sunday, April 19, 2020 | | |
| Chicago Fire FC | | Columbus Crew SC |
| Philadelphia Union | | New York City FC |
| Atlanta United | | Portland Timbers |
MLS Schedule Game 8
| Saturday, April 25, 2020 | | |
| New England Revolution | | Montreal Impact |
| Inter Miami CF | | Toronto FC |
| Chicago Fire FC | | Los Angeles FC |
| Columbus Crew SC | | Philadelphia Union |
| Sporting Kansas City | Minnesota United FC | |
| Colorado Rapids | FC Dallas | |
| Real Salt Lake | Seattle Sounders FC | |
| Portland Timbers | Vancouver Whitecaps FC | |
| LA Galaxy | Houston Dynamo |
| Sunday, April 16, 2020 | | |
| Orlando City SC | | Atlanta United FC |
| DC United | | New York City Red Bulls |
| FC Cincinnati | | San Jose Earthquakes |
| New York City FC | Nashville SC |
MLS Schedule Game 9
| Wednesday, April 29, 2020 | | |
| Colombus Crew SC | | Minnesota United FC |
| Toronto FC | | New England Revolution |
| Real Salt Lake | | Inter Miami CF |
| San Jose Earthquakes | | Vancouver Whitecaps FC |
| Saturday, May 2, 2020 | | |
| Montreal Impact | | Orlando City SC |
| Toronto FC | | Vancouver Whitecaps FC |
| Portland Timbers | | LA Galaxy |
| Seattle Sounders FC | | DC United |
| New England Revolution | | New York City FC |
| New York Red Bulls | | Columbus Crew SC |
| Minnesota United FC | | Colorado Rapids |
| Philadelphia Union | | FC Cincinnati |
| FC Dallas | | Chicago Fire FC |
| Los Angeles FC | Sporting Kansas City |
| Sunday, May 3, 2020 | | |
| Atlanta United FC | | Real Salt Lake |
| Houston Dynamo | | San Jose Earthquakes |
| Nashville SC | | Inter Miami CF |
MLS Schedule Game 10
| Wednesday, May 6, 2020 | | |
| Orlando City SC | | Houston Dynamo |
| FC Cincinnati | | New York Red Bulls |
| Colorado Rapids | | LA Galaxy |
| Saturday, May 9, 2020 | | |
| Columbus Crew SC | | Montreal Impact |
| Chicago Fire FC | | Inter Miami CF |
| Sporting Kansas City | | Toronto FC |
| DC United | | Houston Dynamo |
| FC Cincinnati | | New England Revolution |
| Orlando City SC | | Minnesota United FC |
| Nashville SC | | FC Dallas |
| Philadelphia Union | | Atlanta United FC |
| Real Salt Lake | | Portland Timbers |
| San Jose Earthquakes | | Los Angeles FC |
| Seattle Sounders FC | Colorado Rapids |
| Sunday, May 10, 2020 | | |
| LA Galaxy | | New York Red Bulls |
MLS Schedule Game 11
| Wednesday, May 13, 2020 | | |
| New York City FC | | Toronto FC |
| Minnesota United FC | | Real Salt Lake |
| Nashville SC | | Philadelphia Union |
| San Jose Earthquakes | Seattle Sounders FC |
| Saturday, May 16, 2020 | | |
| Montreal Impact | | Chicago Fire FC |
| New York Red Bulls | | Atlanta United FC |
| Los Angeles FC | | LA Galaxy |
| Toronto FC | | FC Cincinnati |
| DC United | | Orlando City SC |
| New York City FC | | Colorado Rapids |
| New England Revolution | | Columbus Crew SC |
| Vancouver Whitecaps FC | | Nashville SC |
| Inter Miami CF | | Minnesota United FC |
| Philadelphia Union | | Sporting Kansas City |
| FC Dallas | | Houston Dynamo |
| Real Salt Lake | San Jose Earthquakes | |
| Portland Timbers | Seattle Sounders FC |
MLS Schedule Game 12
| Saturday, May 23, 2020 | | |
| Montreal Impact | | San Jose Earthquakes |
| Real Salt Lake | | LA Galaxy |
| Vancouver Whitecaps FC | | FC Dallas |
| New England Revolution | | Toronto FC |
| New York red Bulls | | DC United |
| Orlando City SC | | Columbus Crew SC |
| Chicago Fire FC | | FC Cincinnati |
| Minnesota United FC | | Portland Timbers |
| Houston Dynamo | | Nashville SC |
| Sporting Kansas City | | Seattle Sounders FC |
| Colorado Rapids | | Philadelphia Union |
| Sunday, May 24, 2020 | | |
| Atlanta United FC | | Inter Miami CF |
| Los Angeles FC | New York City FC |
MLS SChedule Game 13
| Wednesday, May 27, 2020 | | |
| Atlanta United FC | | Toronto FC |
| Columbus Crew SC | | Vancouver Whitecaps FC |
| Chicago Fire FC | | Portland Timbers |
| Inter Miami CF | | FC Cincinnati |
| LA Galaxy | DC United | |
| Seattle Sounders FC | Montreal Impact |
MLS Schedule Game 14
| Saturday, May 30, 2020 | | |
| San Jose Earthquakes | | Atlanta United FC |
| Toronto FC | | Inter Miami CF |
| FC Cincinnati | | Nashville SC |
| Orlando City SC | | Portland Timbers |
| New York red Bulls | | DC United |
| Chicago Fire FC | | New England Revolution |
| DC United | | Vancouver Whitecaps FC |
| Los Angeles FC | | Houston Dynamo |
| Philadelphia Union | | Coumbus Crew SC |
| FC Dallas | | Sporting Kansas City |
| Sunday, May 31, 2020 | | |
| Montreal Impact | | Colorado Rapids |
| New York City FC | | New York Red Bulls |
| Seattle Sounders FC | Real Salt Lake | |
| LA Galaxy | Minnesota United FC |
MLS Schedule Game 15
| Saturday, June 6, 2020 | | |
| New York Red Bulls | | Philadelphia Union |
| New England Revolution | | DC United |
| Real Salt Lake | FC Dallas | |
| Sporting Kansas City | Orlando City SC | |
| Vancouver Whitecaps FC | Montreal Impact |
MLS Schedule Game 16
| Saturday, June 13, 2020 | | |
| Portland Timbers | | Sporting Kansas City |
| Columbus Crew SC | | Chicago Fire FC |
| Orlando City SC | | New York Red Bulls |
| Toronto FC | | Montreal Impact |
| DC United | | FC Cincinnati |
| Inter Miami CF | FC Dallas | |
| Minnesota United FC | Nashville SC | |
| Philadelphia Union | Real Salt Lake | |
| Houston Dynamo | Atlanta United FC | |
| Colorado Rapids | Los Angeles FC | |
| LA Galaxy | San Jose Earthquakes | |
| Vancouver Whitecaps FC | Seattle Sounders FC |
| Sunday, June 14, 2020 | | |
| New York City FC | | New England Revolution |
MLS Schedule Game 17
| Wednesday, June 17, 2020 | | |
| Montreal Impact | | Inter Miami CF |
| New York City FC | | Atlanta United |
| New England revolution | | Seattle Sounders FC |
| Toronto FC | | Chicago Fire FC |
| FC Dallas | | Columbus Crew SC |
| Sporting Kansas City | | LA Galaxy |
| Vancouver Whitecaps FC | | New York Red Bulls |
| Los Angeles FC | | Minnesota United FC |
| Portland Timbers | | Colorado Rapids |
MLS Schedule Game 18
| Saturday, June 20, 2020 | | |
| Atlanta United FC | | Philadelphia Union |
| Montreal Impact | | Los Angeles FC |
| Columbus Crew SC | | DC United |
| FC Cincinnati | | New York City FC |
| New England Revolution | | Orlando City SC |
| Inter Miami CF | | Chicago Fire FC |
| FC Dallas | | Minnesota United FC |
| Colorado Rapids | | Toronto FC |
| Sporting Kansas City | | Vancouver Whitecaps FC |
| Real Salt Lake | Houston Dynamo | |
| San Jose Earthquakes | Nashville SC |
| Sunday, June 21, 2020 | | |
| LA Galaxy | | Seattle Sounders FC |
| New York Red Bulls | | Portland Timbers |
MLS Schedule Game 19
| Saturday, June 27, 2020 | | |
| Seattle Sounders FC | | New York City FC |
| Philadelphia Union | | Vancouver Whitecaps FC |
| Columbus Crew SC | | Atlanta United FC |
| FC Cincinnati | | FC Dallas |
| New York Red Bulls | | Montreal Impact |
| Chicago Fire FC | | Orlando City FC |
| DC United | | Minnesota United FC |
| Inter Miami CF | | New England Revolution |
| Toronto FC | | Real Salt Lake |
| Houston Dynamo | Colorado Rapids | |
| San Jose Earthquakes | LA Galaxy | |
| Los Angeles FC | Nashville SC |
| Sunday, June 28, 2020 | | |
| Sporting Kansas City | | Portland Timbers |
| Wednesday, July 1, 2020 | | |
| Atlanta United FC | | Montreal Impact |
| New York City FC | | Orlando City SC |
| FC Cincinnati | | Inter Miami CF |
| DC United | | FC Dallas |
| Minnesota United FC | | Vancouver Whitecaps FC |
| Real Salt Lake | | Sporting Kansas City |
| LA Galaxy | | Nashville SC |
| Portland Timbers | | Columbus Crew SC |
| Friday, July 3, 2020 | | |
| Houston Dynamo | | New England Revolution |
MLS Schedule Game 21
| Saturday, July 4, 2020 | | |
| Atlanta United FC | | DC United |
| Montreal Impact | | Philadelphia Union |
| Orlando City SC | | Toronto FC |
| FC Dallas | | San Jose Earthquakes |
| Colorado Rapids | | New York Red Bulls |
| Vancouver Whitecaps | | FC Cincinnati |
| LA Galaxy | | Real Salt Lake |
| Sunday, July 5, 2020 | | |
| Columbus Crew SC | | Inter Miami CF |
| Sporting Kansas City | Los Angeles FC | |
| Chicago Fire FC | New York City FC | |
| Nashville SC | Portland Timbers | |
| Seattle Sounders FC | Minnesota United FC |
| Wednesday, July 8, 2020 | | |
| TBD | | Montreal Impact |
| TBD | | Toronto FC |
| TBD | | Vancouver Whitecaps FC |
| New England Revolution | | Atlanta United FC |
| Chicago Fire FC | | Philadelphia Union |
| NY Red Bulls | | Seattle Sounders FC |
| Los Angeles FC | | Colorado Rapids |
| Sunday, July 10, 2020 | | |
| Orlando City SC | | Inter Miami CF |
| Saturday, July 11, 2020 | | |
| New York Red Bulls | | Houston Dynamo |
| Montreal Impact | | Columbus Crew SC |
| New England Revolution | | Nashville SC |
| Philadelphia Union | | Toronto FC |
| Chicago Fire FC | | Dc United |
| FC Dallas | | LA Galaxy |
| Sporting Kansas City | | FC Cincinnati |
| Colorado Rapids | | Portland Timbers |
| Real Salt Lake | | Vancouver Whitecaps FC |
| San Jose Earthquakes | | New York City FC |
| Sunday, July 12, 2020 | | |
| Atlanta United FC | | Seattle Sounders FC |
| Minnesota United FC | | Los Angeles FC |
| Wednesday, July 15, 2020 | | |
| Montreal Impact | | TBD |
| Toronto FC | | TBD |
| New York City FC | FC Cincinnati |
| Saturday, July 18, 2020 | | |
| LA Galaxy | | Atlanta United FC |
| Toronto FC | | Seattle Sounders FC |
| DC United | Montreal Impact | |
| Inter Miami CF | New York City FC | |
| Minnesota United FC | Sporting Kansas City | |
| Mashville SC | Real Salt Lake | |
| Philadelphia Union | New England Revolution | |
| FC Dallas | Orlando City SC | |
| Colorado Rapids | Chicago Fire FC | |
| Houston Dynamo | Vancouver Whitecaps FC | |
| Portland Timbers | San Jose Earthquakes |
| Sunday, July 19, 2020 | | |
| New York Red Bulls | | Los Angeles FC |
| FC Cincinnati | | Columbus Crew SC |
| Wesnesday, July 22, 2020 | | |
| Nashville SC | | Los Angeles FC |
| Seattle Sounders | | Houston Dynamo |
| Thursday, June 23, 2020 | | |
| Inter Miami CF | | Atlanta United FC |
| Saturday, July 25, 2020 | | |
| Seattle Sounders FC | | Los Angeles FC |
| New York City FC | | Montreal Impact |
| Columbus Crew SC | Colorado Rapids | |
| FC Cincinnati | Chicago Fire FC | |
| New England Revolution | New York Red Bulls | |
| Orlando City SC | Philadelphia Union | |
| Toronto FC | DC United | |
| Nashville SC | San Jose Earthquakes | |
| Sporting Kansas City | FC Dallas | |
| Real Salt Lake | Minnesota United FC | |
| Vancouver Whitecaps FC | LA Galaxy | |
| Portland Timbers | Houston Dynamo |
| Saturday, August 1, 2020 | | |
| Atlanta United FC | | New York City FC |
| Montreal Impact | | Sporting Kansas City |
| FC Cincinnati | Orlando City SC | |
| New York Red Bulls | FC Dallas | |
| Chicago Fire FC | Toronto FC | |
| DC United | Columbus Crew SC | |
| Nashville SC | Minnesota United FC | |
| Philadelphia Union | Inter Miami CF | |
| Houston Dynamo | Real Salt Lake | |
| Colorado Rapids | Vancouver Whitecaps FC | |
| San Jose Earthquakes | New England Revolution |
| Sunday, August 2, 2020 | | |
| Los Angeles FC | | Seattle Sounders FC |
| LA Galaxy | | Portland Timbers |
| Wednesday, August 5, 2020 | | |
| Chicago Fire FC | | San Jose Earthquakes |
| Nashville SC | | Houston Dynamo |
| Saturday, August 8, 2020 | | |
| Seattle Sounders FC | | Sporting Kansas City |
| Montreal Impact | | New York Red Bulls |
| New York City FC | Philadelphia Union | |
| Toronto FC | Columbus Crew SC | |
| Inter Miami CF | DC United | |
| FC Dallas | Real Salt Lake | |
| Vancouver Whitecaps | Orlando City SC | |
| Portland Timbers | FC Cincinnati |
| Sunday, August 9, 2020 | | |
| Minnesota United FC | | Atlanta United FC |
| Chicago Fire FC | | LA Galaxy |
| Colorado Rapids | Nashville SC | |
| San Jose Earthquakes | Houston Dynamo |
| Wednesday, August 12, 2020 | | |
| TBD | | TBD |
| TBD | | TBD |
| New York City FC | Columbus Crew SC | |
| Atlanta United FC | New England Revolution | |
| FC Cincinnati | Los Angeles FC |
| Saturday, August 15, 2020 | | |
| Toronto FC | | Philadelphia Union |
| Columbus Crew SC | | New England Revolution |
| New York red Bulls | Chicago Fire FC | |
| Orlando City SC | DC United | |
| Nashville SC | Vancouver Whitecaps FC | |
| FC Dallas | Colorado Rapids | |
| Houston Dynamo | New York City FC | |
| Sporting Kansas City | San Jose Earthquakes | |
| Real Salt Lake | Montreal Impact | |
| LA Galaxy | FC Cincinnati |
| Sunday, August 16, 2020 | | |
| Atlanta United Fc | | Los Angeles FC |
| Minnesota United Fc | | Seattle Sounders FC |
| Portland Timbers | Inter Miami CF |
| Wednesday, August 19, 2020 | | |
| TBD | | TBD |
| TBD | | TBD |
| Thursday, August 20, 2020 | | |
| Inter Miami CF | | Orlando City SC |
| Houston Dynamo | | Fc Dallas |
| Saturday, August 22, 2020 | | |
| Seattle Sounders FC | | Portland Timbers |
| Columbus Crew SC | | FC Cincinnati |
| New England Revolution | Sporting Kansas City | |
| DC United | Philadelphia Union | |
| Minnesota United FC | Chicago Fire FC | |
| Montreal Impact | Toronto FC | |
| Colorado Rapids | Real Salt Lake | |
| Vancouver Whitecaps FC | San Jose Earthquakes |
| Sunday, August 23, 2020 | | |
| Atlanta United FC | | Orlando City SC |
| LA Galaxy | | Los Angeles FC |
| New York Red Bulls | New York City FC | |
| Fc Dallas | Nashville SC |
| Wednesday, August 26, 2020 | | |
| Montreal Impact | | Atlanta United FC |
| Los Angeles FC | | Vancouver Whitecaps FC |
| Friday, August 28, 2020 | | |
| Inter Miami CF | | Seattle Sounders FC |
| Saturday, August 29, 2020 | | |
| FC Cincinnati | | Montreal Impact |
| DC United | | New England Revolution |
| Philadelphia Union | Orlando City SC | |
| Sporting Kansas City | Columbus Crew SC | |
| Colorado Rapids | Minnesota United FC | |
| Houston Dynamo | Toronto FC | |
| Real Salt Lake | Nashville SC | |
| San Jose Earthquakes | FC Dallas | |
| Vancouver Whitecaps FC | Chicago Fire FC |
| Sunday, August 30, 2020 | | |
| New York City FC | | LA Galaxy |
| Atlanta United FC | | New York Red Bulls |
| Portland Timbers | Los Angeles FC |
| Friday, September 4, 2020 | | |
| Montreal Impact | | DC United |
| Saturday, September 5, 2020 | | |
| Chicago Fire | | Sporting Kansas City |
| FC Dallas | Portland Timbers |
| Friday, September 11, 2020 | | |
| Montreal Impact | | New York City FC |
| Los Angeles FC | FC Dallas |
| Saturday, September 12, 2020 | | |
| NY Red Bulls | | Inter Miami CF |
| Columbus Crew SC | | Houston Dynamo |
| New England Revolution | | Philadelphia Union |
| Orlando City SC | | Nashville SC |
| Toronto FC | | Atlanta United FC |
| Colorado Rapids | | Sporting Kansas City |
| Real Salt Lake | | FC Cincinnati |
| San Jose Earthquakes | | Portland Timbers |
| Sunday, September 13, 2020 | | |
| DC United | | Chicago Fire FC |
| Seattle Sounders FC | | LA Galaxy |
| Vancouver Whitecaps | | Minnesota United |
| Wednesday, September 16, 2020 | | |
| TBD | | TBD |
| New York City FC | | Inter Miami CF |
| Nashville SC | | Colorado Rapids |
| Houston Dynamo | Los Angeles FC | |
| Seattle Sounders | San Jose Earthquakes |
| Saturday, September 19, 2020 | | |
| Atlanta United | | Chicago Fire FC |
| Vancouver Whitecaps | | Houston Dynamo |
| Columbus Crew SC | | NY Red Bulls |
| FC Cincinnati | Philadelphia Union | |
| Orlando City SC | New York City FC | |
| Inter Miami CF | Montreal Impact | |
| Minnesota United | New England Revolution | |
| Sporting Kansas City | Nashville SC | |
| Portland Timbers | Toronto FC | |
| San Jose Earthquakes | Real Salt Lake | |
| LA Galaxy | Colorado Rapids |
| Sunday, September 20, 2020 | | |
| FC Dallas | | Seattle Sounders |
| Los Angeles FC | | DC United |
| Wednesday, September 23, 2020 | | |
| TBD | | TBD |
| Saturday, September 26, 2020 | | |
| Los Angeles FC | | San Jose Earthquakes |
| Atlanta United FC | | Columbus Crew SC |
| New York City FC | | DC United |
| Toronto FC | Orlando City SC | |
| FC Cincinnati | Minnesota United FC | |
| New England Revolution | Inter Miami CF | |
| Chicago Fire FC | Montreal Impact | |
| Nashville SC | FC Galaxy | |
| Colorado Rapids | Seattle Sounders SC | |
| FC Dallas | Vancouver Whitecaps | |
| Portland Timbers | Real Salt Lake |
| Sunday, September 27, 2020 | | |
| Houston Dynamo | | Sporting Kansas City |
| Philadelphia Union | | NY Red Bulls |
| New England Revolution | | Philadelphia Union |
| Sunday, October 4, 2020 | | |
| DC United | | Atlanta United FC |
| Inter Miami CF | | Columbus Crew SC |
| LA Galaxy | | FC Dallas |
| Minnesota United FC | Houston Dynamo | |
| Montreal Impact | FC Cincinnati | |
| NY Red Bulls | Toronto FC | |
| Orlando City SC | New England Revolution | |
| Philadelphia Union | Chicago Fire FC | |
| Real Salt Lake | Los Angeles FC | |
| San Jose Earthquakes | Colorado Rapids | |
| Seattle Sounders FC | Nashville SC | |
| Sporting Kansas City | New York City FC | |
| Vancouver Whitecaps | Portland Timbers |